Complete regression of a previously untreated melanoma brain metastasis with ipilimumab

Melanoma Res. 2010 Jun;20(3):247-50. doi: 10.1097/CMR.0b013e3283364a37.


Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a patient with stage IV melanoma. This case and earlier reports provide support for the further evaluation of ipilimumab in melanoma patients with brain metastasis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antibodies, Monoclonal / pharmacology*
  • Antineoplastic Agents / pharmacology*
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / secondary*
  • Humans
  • Ipilimumab
  • Male
  • Melanoma / drug therapy*
  • Melanoma / pathology*
  • Neoplasm Metastasis
  • Regression Analysis
  • Remission Induction
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology*
  • Treatment Outcome


  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Ipilimumab