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. 2010 Mar;46(2):140-9.
doi: 10.3164/jcbn.09-100. Epub 2010 Feb 24.

Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects With Potential Metabolic Syndrome-An Open Label Pilot Study

Free PMC article

Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects With Potential Metabolic Syndrome-An Open Label Pilot Study

Atsunori Nakao et al. J Clin Biochem Nutr. .
Free PMC article


Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5-2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic syndrome. Hydrogen rich water was produced, by placing a metallic magnesium stick into drinking water (hydrogen concentration; 0.55-0.65 mM), by the following chemical reaction; Mg + 2H(2)O --> Mg (OH)(2) + H(2). The consumption of hydrogen rich water for 8 weeks resulted in a 39% increase (p<0.05) in antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease (p<0.05) in thiobarbituric acid reactive substances (TBARS) in urine. Further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4. There was no change in fasting glucose levels during the 8 week study. In conclusion, drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome. The portable magnesium stick was a safe, easy and effective method of delivering hydrogen rich water for daily consumption by participants in the study.

Keywords: drinking water; hydrogen; magnesium; metabolic syndrome; oxidative stress.


Fig. 1
Fig. 1
A. Magnesium stick and the methods to generate hydrogen water in 500 ml bottles of drinking water. A plastic shelled product consisting of metallic magnesium (99.9% pure) and natural stones in the polypropylene containers combined with ceramics (Doctor SUISOSUI®, Friendear, Tokyo, Japan) was used to produce hydrogen. The product was capable of generating hydrogen when placed in drinking water by the following chemical reaction; Mg + 2H2O → Mg (OH)2 + H2. B. Hydrogen concentrations in the water bottle (n = 3). The hydrogen concentration in a water bottle was maintained between 0.55 and 0.65 mM over an 8 week period.

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