Influence of bovine lactoferrin on selected probiotic bacteria and intestinal pathogens

Biometals. 2010 Jun;23(3):593-6. doi: 10.1007/s10534-010-9318-0. Epub 2010 Mar 9.


This study investigated the effects of bovine lactoferrin (BLf) on the growth of different groups of bacteria in vitro. BLf showed a significant inhibitory effect on the growth of selected pathogens but not probiotics. BLf, in combination with probiotics, has the potential to influence the composition of the gut microflora via inhibition of intestinal pathogens with no significant effect on probiotic bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / immunology
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacteria / immunology
  • Bacteria / pathogenicity*
  • Cattle
  • Intestines / drug effects*
  • Intestines / immunology
  • Intestines / microbiology*
  • Lactoferrin / immunology
  • Lactoferrin / pharmacology*
  • Microbial Sensitivity Tests
  • Probiotics*


  • Anti-Bacterial Agents
  • Lactoferrin