GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep

Adv Exp Med Biol. 2010:669:259-62. doi: 10.1007/978-1-4419-5692-7_52.

Abstract

The aim of this study was to determine if GABA(B) receptors play a role in suppressing upper airway muscle tone in rapid eye movement (REM) sleep. The results reported herein indicate that GABA(B) receptors, acting in concert with GABA(A) and glycine receptors, play a role in mediating REM sleep atonia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzylamines / pharmacology
  • Electroencephalography
  • Electromyography
  • Glycine / metabolism*
  • Male
  • Masseter Muscle / drug effects
  • Masseter Muscle / metabolism
  • Masseter Muscle / physiology
  • Motor Neurons / cytology
  • Motor Neurons / drug effects
  • Motor Neurons / metabolism*
  • Phosphinic Acids / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, GABA-B / metabolism
  • Respiratory System / cytology*
  • Respiratory System / metabolism
  • Sleep, REM / drug effects
  • Sleep, REM / physiology*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Benzylamines
  • Phosphinic Acids
  • Receptors, GABA-B
  • CGP 52432
  • gamma-Aminobutyric Acid
  • Glycine