Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea

Adv Exp Med Biol. 2010;669:281-4. doi: 10.1007/978-1-4419-5692-7_57.

Abstract

Using rapid-eye-movement (REM) sleep as a model state, we sought to determine whether noradrenaline functions to strengthen upper airway muscle tone by amplifying glutamatergic excitation on to trigeminal motoneurons. We report that noradrenaline cannot trigger motoneuron excitability on its own, instead acting to facilitate glutamatergic motor excitation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electromyography
  • Glutamic Acid / metabolism
  • Male
  • Masseter Muscle / physiology
  • Masseter Muscle / physiopathology
  • Motor Neurons / metabolism*
  • Norepinephrine / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Sleep Apnea Syndromes / metabolism*
  • Sleep Apnea Syndromes / pathology*
  • Sleep Apnea Syndromes / physiopathology
  • Sleep* / physiology
  • Sleep, REM / physiology
  • Trigeminal Nerve / cytology*
  • Trigeminal Nerve / pathology*

Substances

  • Glutamic Acid
  • Norepinephrine