Cyclic AMP signaling in pancreatic islets

Adv Exp Med Biol. 2010;654:281-304. doi: 10.1007/978-90-481-3271-3_13.

Abstract

Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet beta-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet beta-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet beta-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the beta-cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Calcium / metabolism
  • Cyclic AMP / metabolism*
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Exocytosis
  • Guanine Nucleotide Exchange Factors / metabolism
  • Humans
  • Insulin / metabolism*
  • Insulin Secretion
  • Insulin-Secreting Cells / cytology
  • Islets of Langerhans / cytology*
  • Islets of Langerhans / pathology
  • Mice
  • Models, Biological
  • Protein Kinase C / metabolism
  • Signal Transduction

Substances

  • Guanine Nucleotide Exchange Factors
  • Insulin
  • RAPGEF3 protein, human
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C
  • Calcium