Acute changes in kidney function following extracorporeal shock wave lithotripsy for renal stones

Br J Urol. 1991 Mar;67(3):241-5. doi: 10.1111/j.1464-410x.1991.tb15126.x.


Seventeen patients were subjected to analysis of various renal functional parameters before and after extracorporeal shock wave lithotripsy (ESWL) for renal stones. Thirteen patients were observed at 2 weeks and 3 months. Glomerular filtration rate (GFR) was not influenced by ESWL as based on unchanged serum levels of creatinine, beta 2-microglobulin and creatinine clearance. A significant increase in urinary excretion of beta 2-microglobulin, N-acetyl-beta-glucosaminidase and alkaline phosphatase, with return to pre-treatment values within 4 to 5 days, reflected transient disturbances in proximal tubular function. Urinary albumin excretion was increased 0-24 h after ESWL. No significant alterations were observed in plasma renin activity or serum aldosterone due to ESWL. Serum lactic dehydrogenase remained significantly increased for 2 weeks. In addition, significant changes in several blood and urine parameters were caused by immersion in water and intravenous infusions during treatment and were not specifically due to ESWL.

MeSH terms

  • Acetylglucosaminidase / urine
  • Adolescent
  • Adult
  • Aged
  • Albuminuria / etiology
  • Alkaline Phosphatase / urine
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney / physiopathology*
  • Kidney Calculi / physiopathology
  • Kidney Calculi / therapy*
  • Kidney Calculi / urine
  • L-Lactate Dehydrogenase / blood
  • Lithotripsy / adverse effects*
  • Male
  • Middle Aged
  • Prospective Studies
  • Time Factors
  • beta 2-Microglobulin / urine


  • beta 2-Microglobulin
  • L-Lactate Dehydrogenase
  • Alkaline Phosphatase
  • Acetylglucosaminidase