In 2007 and 2008, field trials were carried out with different standard and drift-reducing nozzles in sugar beet, maize, chicory, Belgian endive (all herbicide applications), wheat (fungicide application) and potatoes (Haulm killing herbicide application). The effect of nozzle type (standard flat fan, low-drift flat fan, air injection), nozzle size (ISO 02, 03 and 04) and application volume on the biological efficacy was investigated. All applications were done using a plot sprayer with volume rates ranging from 160 to 320 l.ha(-1) at recommended dose rates with commonly used (mix of) plant protection products. For each crop, the experiments included four replicates in a randomized block design. Depending on the type of application, the efficacy was measured in terms of weed control, disease and yield level, percentage dead leaf and stem, etc. In a previous research, drift and droplet characteristics of the different techniques were measured. In general no important effect of application technique on biological efficacy was observed for the tested herbicide and fungicide applications within the interval of volume rates and droplet size tested. Drift-reducing nozzles performed similar as conventional nozzles under good spraying conditions and using a correct spray application technique.