Helminth-derived immunomodulators: can understanding the worm produce the pill?

Nat Rev Immunol. 2010 Apr;10(4):278-84. doi: 10.1038/nri2730. Epub 2010 Mar 12.


Helminths may protect humans against allergic and autoimmune diseases and, indeed, defined helminth-derived products have recently been shown to prevent the development of such inflammatory diseases in mouse models. Here, we propose that helminth-derived products not only have therapeutic potential but can also be used as unique tools for defining key molecular events in the induction of an anti-inflammatory response and, therefore, for defining new therapeutic targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Helminth Proteins / immunology*
  • Helminthiasis / immunology*
  • Humans
  • Hypersensitivity / immunology
  • Immunologic Factors / immunology*


  • Helminth Proteins
  • Immunologic Factors