The natural history of soy allergy

J Allergy Clin Immunol. 2010 Mar;125(3):683-6. doi: 10.1016/j.jaci.2009.12.994.


Background: Soy allergy is very common, affecting approximately 0.4% of children. It is generally thought that the majority of children with soy allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with soy allergy.

Objective: We sought to describe the natural history of soy allergy and identify predictors of oral tolerance/outgrowing soy allergy.

Methods: The records of patients with soy allergy seen in a tertiary referral clinic were reviewed. Data collected included soy allergy-related symptoms, history of other food allergies and atopic diseases, soy-specific IgE levels, peanut-specific IgE levels, and food challenge results.

Results: One hundred thirty-three patients were studied (96 male and 37 female patients). Eighty-five (64%) had asthma, 95 (71%) had allergic rhinitis, and 108 (85%) had atopic dermatitis. Eighty-eight percent had concomitant peanut allergy. The median age at the initial visit was 1 year (range, 2 months to 17.5 years); the median duration of follow-up was 5 years (range, 1-19 years). Kaplan-Meier analysis predicted resolution of soy allergy in 25% by age 4 years, 45% by age 6 years, and 69% by age 10 years. By age 6 years, 59% of children with a peak soy IgE level of less than 5 kU/L, 53% of children with a peak s-IgE level of 5 to 9.9 kU/L, 45% of children with a peak s-IgE level of 10 to 49.9 kU/L, and 18% of children with a peak s-IgE level of greater than 50 kU/L had outgrown soy allergy (P < .01 for trend).

Conclusions: In this referral population approximately 50% of children with soy allergy outgrew their allergy by age 7 years. Absolute soy IgE levels were useful predictors of outgrowing soy allergy.

MeSH terms

  • Adolescent
  • Age of Onset
  • Child
  • Child, Preschool
  • Female
  • Food Hypersensitivity / blood
  • Food Hypersensitivity / epidemiology*
  • Food Hypersensitivity / immunology*
  • Humans
  • Immunoglobulin E / blood
  • Immunoglobulin E / immunology
  • Infant
  • Male
  • Soybeans / adverse effects*
  • Soybeans / immunology*
  • Young Adult


  • Immunoglobulin E