Directing systemic oncolytic viral delivery to tumors via carrier cells

Cytokine Growth Factor Rev. Apr-Jun 2010;21(2-3):119-26. doi: 10.1016/j.cytogfr.2010.02.004. Epub 2010 Mar 11.

Abstract

The systemic administration of oncolytic virus (OV) is often inefficient due to clearance of the virus by host defense mechanism and spurious targeting of non-cancer tissues through the bloodstream. Cell mediated OV delivery could hide the virus from host defenses and direct them toward tumors: Mesenchymal and neural stem cells have been described to possess tumor-homing ability as well as the capacity to deliver OVs. In this review, we will focus on approaches where OV and carrier cells are utilized for cancer therapy. Effective cellular internalization and replication of OVs need to occur both in cancer and carrier cells. We thus will discuss the current challenges faced by the use of OV delivery via carrier cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adenoviridae / genetics
  • Adenoviridae / metabolism
  • Genetic Vectors*
  • Humans
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / virology
  • Neoplasms / therapy*
  • Neurons / cytology
  • Neurons / virology
  • Oncolytic Virotherapy / methods*
  • Oncolytic Viruses / genetics
  • Oncolytic Viruses / physiology*
  • Stem Cells / cytology
  • Stem Cells / virology*
  • Transduction, Genetic
  • Virus Replication