A systematic literature review of vitamin D and ovarian cancer

Am J Obstet Gynecol. 2010 Jul;203(1):70.e1-8. doi: 10.1016/j.ajog.2010.01.062. Epub 2010 Mar 12.


Objective: We assessed the evidence supporting a reduction in risk for ovarian cancer occurrence or mortality with greater vitamin D exposures.

Study design: This review followed standard guidelines for systematic literature reviews. The diverse study designs precluded a quantitative metaanalysis. Therefore studies are summarized via tables and abstracted information.

Results: Approximately half of the ecologic and case-control studies reported reductions in incidence or mortality with increasing geographic latitude, solar radiation levels, or dietary/supplement consumption of vitamin D, whereas the other half reported null associations. The cohort studies reported no overall risk reduction with increasing dietary/supplement consumption of vitamin D or with plasma levels of vitamin D prior to diagnosis, although vitamin D intakes were relatively low in all studies.

Conclusion: There is no consistent or strong evidence to support the claim made in numerous review articles that vitamin D exposures reduce the risk for ovarian cancer occurrence or mortality.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Dietary Supplements
  • Female
  • Humans
  • Ovarian Neoplasms / prevention & control*
  • Vitamin D / administration & dosage*


  • Vitamin D