An RNA-mediated Silencing Pathway Utilizes the Coordinated Synthesis of Two Distinct Populations of siRNA

Mol Cell. 2010 Mar 12;37(5):593-5. doi: 10.1016/j.molcel.2010.02.013.

Abstract

In this issue of Molecular Cell, Gent et al. (2010) describe the participation of two siRNA populations, generated by two different RNA-directed RNA polymerases, in a pathway to silence expression of endogenous genes in Caenorhabditis elegans.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / enzymology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism*
  • Eukaryotic Initiation Factors / metabolism
  • Mutation
  • Phosphorylation
  • RNA Interference*
  • RNA Replicase / genetics
  • RNA Replicase / metabolism*
  • RNA Stability
  • RNA, Messenger / metabolism*
  • RNA, Small Interfering / biosynthesis*
  • Ribonuclease III / metabolism
  • Transcription, Genetic*

Substances

  • Caenorhabditis elegans Proteins
  • Eukaryotic Initiation Factors
  • RNA, Messenger
  • RNA, Small Interfering
  • RNA Replicase
  • RNA-directed RNA polymerase RRF-3, C elegans
  • Ribonuclease III