Box H/ACA small ribonucleoproteins

Mol Cell. 2010 Mar 12;37(5):597-606. doi: 10.1016/j.molcel.2010.01.032.


Box H/ACA RNAs represent an abundant, evolutionarily conserved class of small noncoding RNAs. All H/ACA RNAs associate with a common set of proteins, and they function as ribonucleoprotein (RNP) enzymes mainly in the site-specific pseudouridylation of ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). Some H/ACA RNPs function in the nucleolytic processing of precursor rRNA (pre-rRNA) and synthesis of telomeric DNA. Thus, H/ACA RNPs are essential for three fundamental cellular processes: protein synthesis, mRNA splicing, and maintenance of genome integrity. Recently, great progress has been made toward understanding of the biogenesis, intracellular trafficking, structure, and function of H/ACA RNPs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Archaeal Proteins / metabolism
  • Coiled Bodies / metabolism*
  • Evolution, Molecular
  • Genomic Instability
  • Humans
  • Intramolecular Transferases / metabolism
  • Models, Molecular
  • Nucleic Acid Conformation
  • Protein Biosynthesis
  • Protein Conformation
  • Pseudouridine / metabolism
  • RNA Processing, Post-Transcriptional
  • RNA Splicing
  • RNA, Messenger / metabolism
  • RNA, Ribosomal / metabolism
  • RNA, Untranslated / chemistry
  • RNA, Untranslated / metabolism*
  • Ribonucleoproteins, Small Nuclear / biosynthesis
  • Ribonucleoproteins, Small Nuclear / chemistry
  • Ribonucleoproteins, Small Nuclear / metabolism*
  • Telomerase / metabolism


  • Archaeal Proteins
  • RNA, Messenger
  • RNA, Ribosomal
  • RNA, Untranslated
  • Ribonucleoproteins, Small Nuclear
  • Pseudouridine
  • Telomerase
  • Intramolecular Transferases
  • pseudouridine synthases