Circadian clock control of the cellular response to DNA damage

FEBS Lett. 2010 Jun 18;584(12):2618-25. doi: 10.1016/j.febslet.2010.03.017. Epub 2010 Mar 15.


Mammalian cells possess a cell-autonomous molecular clock which controls the timing of many biochemical reactions and hence the cellular response to environmental stimuli including genotoxic stress. The clock consists of an autoregulatory transcription-translation feedback loop made up of four genes/proteins, BMal1, Clock, Cryptochrome, and Period. The circadian clock has an intrinsic period of about 24 h, and it dictates the rates of many biochemical reactions as a function of the time of the day. Recently, it has become apparent that the circadian clock plays an important role in determining the strengths of cellular responses to DNA damage including repair, checkpoints, and apoptosis. These new insights are expected to guide development of novel mechanism-based chemotherapeutic regimens.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Apoptosis / physiology
  • Cell Cycle / genetics
  • Cell Cycle / physiology
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology*
  • DNA Damage*
  • DNA Repair / genetics
  • DNA Repair / physiology
  • DNA Repair Enzymes / genetics
  • DNA Repair Enzymes / metabolism
  • Drug Chronotherapy
  • Humans
  • Models, Biological*
  • Mutation
  • Neoplasms / drug therapy
  • Neoplasms / etiology


  • DNA Repair Enzymes