Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D

J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):86-95. doi: 10.1016/j.jsbmb.2010.02.029. Epub 2010 Mar 19.


Regulatory T cells (TRegs) play a central role in the maintenance of peripheral tolerance. They prevent inappropriate immune responses to ubiquitous allergens in healthy individuals, and contribute to the maintenance of immune homeostasis in the airways. Both Foxp3+ and IL-10+ TReg have been implicated in these functions. Glucocorticoids represent the mainstay of treatment for asthma and other allergic conditions, and evidence that steroids influence TReg function will be reviewed. Growing bodies of epidemiological and immunological data suggest a role for endogenous Vitamin D in immune regulation. This review will discuss the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma.

Publication types

  • Review

MeSH terms

  • Animals
  • Glucocorticoids / immunology*
  • Humans
  • Hypersensitivity / immunology*
  • Immune Tolerance
  • Inflammation / immunology
  • T-Lymphocytes, Regulatory / immunology*
  • Vitamin D / immunology*


  • Glucocorticoids
  • Vitamin D