Selection of bifidobacteria based on adhesion and anti-inflammatory capacity in vitro for amelioration of murine colitis

Julia Preising; David Philippe; Marita Gleinser; Hua Wei; Stephanie Blum; Bernhard J Eikmanns; Jan-Hendrik Niess; Christian U Riedel

doi:10.1128/AEM.03127-09

Selection of bifidobacteria based on adhesion and anti-inflammatory capacity in vitro for amelioration of murine colitis

Appl Environ Microbiol. 2010 May;76(9):3048-51. doi: 10.1128/AEM.03127-09. Epub 2010 Mar 12.

Authors

Julia Preising¹, David Philippe, Marita Gleinser, Hua Wei, Stephanie Blum, Bernhard J Eikmanns, Jan-Hendrik Niess, Christian U Riedel

Affiliation

¹ Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany.

Abstract

Adhesion and anti-inflammatory properties of eight strains of bifidobacteria were tested using the intestinal epithelial cell lines Caco-2, T84, and HT29. Two strains were selected for further assessment of their anti-inflammatory capacity in two murine models of colitis. In vivo results confirmed the high anti-inflammatory capacity of a Bifidobacterium bifidum strain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacterial Adhesion
Bifidobacterium / physiology*
Caco-2 Cells
Colitis / therapy*
Humans
Inflammation Mediators / metabolism
Intestinal Mucosa / microbiology
Mice
Probiotics*

Substances

Inflammation Mediators