Lycopene in treatment of high-grade gliomas: a pilot study

Neurol India. Jan-Feb 2010;58(1):20-3. doi: 10.4103/0028-3886.60389.

Abstract

Background: The therapeutic benefit of lycopene is well established for carcinoma prostate in various clinical trials and has been proposed for other malignancies including high-grade gliomas.

Setting and design: Randomized placebo control study in the Department of Radiation Oncology of a teaching hospital.

Materials and methods: Fifty patients with high-grade gliomas were treated with surgery followed by adjuvant radiotherapy and concomitant paclitaxel. Patients were randomized to receive either oral lycopene (Group A) 8 mg daily with radiotherapy or placebo (Group B). Pre-and post-radiotherapy plasma lycopene levels were measured using high-precision liquid chromatography. McDonald's criteria were used for response assessment. Magnetic resonance imaging (MRI) of brain and Single Photon Emission Computed Tomograph (SPECT) were done three-monthly for two visits and six-monthly thereafter. Primary endpoint was response at six months post radiotherapy. Statistical Analysis Used : The data was analyzed using SPSS Software v10.0 (SPSS corporation Chicago IL) by applying Student's t-test, ANOVA F test, Chi-square test and Karl Pearson Correlation Coefficient.

Results: Median age was 38 years. The commonest histology was glioblastoma multiforme (n = 32). Pre- and post-treatment plasma lycopene levels in the patients in Gropu A were 152 ng/ml and 316 ng/ml and in the patients in Group B were 93 ng/ml and 98 ng/ml (P = 0.009). There was non-significant differences in favor of lycopene between Group A and Group B with higher overall response at six months (P = 0.100), response at last follow-up (P = 0.171) and time to progression (40.83 vs. 26.74 weeks, P = 0.089)., The follow-up duration was significantly higher for Group A than Group B (66.29 vs. 38.71 weeks, P = 0.05).

Conclusions: Addition of nutrition supplements such as lycopene may have potential therapeutic benefit in the adjuvant management of high-grade gliomas.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Antioxidants / administration & dosage*
  • Brain Neoplasms / blood
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / drug therapy*
  • Carotenoids / administration & dosage*
  • Carotenoids / blood
  • Child
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Glioma / blood
  • Glioma / drug therapy*
  • Glioma / radiotherapy
  • Humans
  • Lycopene
  • Male
  • Middle Aged
  • Pilot Projects
  • Radiography
  • Radiotherapy / methods
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult

Substances

  • Antioxidants
  • Carotenoids
  • Lycopene