Endometriosis: new concepts in the pathogenesis

Int J Biochem Cell Biol. 2010 Jun;42(6):778-80. doi: 10.1016/j.biocel.2010.03.008. Epub 2010 Mar 15.


Endometriosis is a gynaecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Though there are several theories, research scientists remain unsure as to the definitive cause(s) of endometriosis. Considering the relevant health problems caused by endometriosis, all new information on the pathogenesis of this disease, may have important clinical implications. Goal of this article is to summarize the latest advances in the pathogenesis of endometriosis, with particular emphasis on the embryological theory, that has been recently re-proposed. The possible clinical implications of these findings will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / pathology*
  • Animals
  • Choristoma*
  • Embryonic Development
  • Endometriosis / etiology*
  • Endometriosis / pathology
  • Endometriosis / physiopathology
  • Endometriosis / therapy
  • Endometrium / embryology*
  • Endometrium / pathology
  • Endometrium / surgery
  • Female
  • Humans
  • Hysterectomy
  • Organogenesis
  • Pregnancy
  • Uterus*