Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus

J Rheumatol. 1991 Jan;18(1):120-4.

Abstract

Previous studies have suggested a role for anti-Ro antibodies in the pathogenesis of neonatal lupus erythematosus (NLE). We reexamined the role of the immune response to the Ro/La particle in the development of NLE using newer and more definitive assay techniques. All 15 infants with congenital heart block and NLE had both anti-Ro and anti-La antibodies. Of 8 patients with cutaneous NLE alone, 2 had anti-Ro antibodies alone while the remaining 6 had both anti-Ro and anti-La antibodies. One woman gave birth to 2 children; one had both Ro and La antibodies and developed congenital heart block, the other had only anti-Ro and anti-U1RNP antibodies and was clinically normal. Our study demonstrates that the presence of anti-Ro and anti-La antibodies define the immune response that is associated with the development of congenital heart block of NLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Antinuclear / analysis
  • Antibody Formation
  • Autoantibodies / analysis
  • Autoantigens / immunology*
  • Female
  • Heart Block / congenital
  • Heart Block / immunology*
  • Humans
  • Infant, Newborn
  • Lupus Erythematosus, Systemic / immunology*
  • Pregnancy
  • RNA, Small Cytoplasmic*
  • Ribonucleoproteins / immunology

Substances

  • Antibodies, Antinuclear
  • Autoantibodies
  • Autoantigens
  • RNA, Small Cytoplasmic
  • Ribonucleoproteins
  • SS-A antigen
  • TROVE2 protein, human