A new prenylated flavanonol from Seseli annuum roots showing protective effect on human lymphocytes DNA

Chem Biodivers. 2010 Mar;7(3):698-704. doi: 10.1002/cbdv.200900067.

Abstract

A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, 1D- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apiaceae / chemistry*
  • Coumarins / chemistry
  • Coumarins / isolation & purification
  • Coumarins / pharmacology
  • DNA / metabolism*
  • Diynes / chemistry
  • Diynes / isolation & purification
  • Diynes / pharmacology
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology
  • Flavonols / chemistry*
  • Flavonols / isolation & purification
  • Flavonols / pharmacology
  • Hemiterpenes / chemistry*
  • Hemiterpenes / isolation & purification
  • Hemiterpenes / pharmacology
  • Humans
  • Lymphocytes / drug effects*
  • Lymphocytes / immunology
  • Plant Roots / chemistry

Substances

  • Coumarins
  • Diynes
  • Fatty Alcohols
  • Flavonols
  • Hemiterpenes
  • seselinonol
  • falcarinol
  • phellopterin
  • falcarindiol
  • DNA