Traditional Chinese medicine Ningdong granule: the beneficial effects in Tourette's disorder

J Int Med Res. Jan-Feb 2010;38(1):169-75. doi: 10.1177/147323001003800119.


This 8-week, randomized, placebo-controlled, double-blind clinical study investigated the short-term effectiveness and safety of the traditional Chinese medicine, Ningdong (ND) granule in paediatric subjects (aged 7 - 18 years) with Tourette's disorder (TD). Subjects received either 1 g/kg per day ND granule (n = 33) or placebo (n = 31) and tics were measured at baseline and after 4 and 8 weeks of treatment. Body mass index, electrocardiogram and laboratory measures were recorded at baseline and at week 8. After 8 weeks of treatment with ND granule, subjects exhibited a 41.39% reduction in the total tic score while the placebo group showed a 10.79% decrease. Regarding side-effects, two subjects reported loss of appetite and one experienced constipation in the ND granule group. There were no significant changes in laboratory and physical examinations. These results suggest that ND granule is both effective and safe, and may be a good candidate for the treatment of patients with TD.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Double-Blind Method
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Male
  • Medicine, Chinese Traditional*
  • Placebos
  • Tourette Syndrome / drug therapy*
  • Treatment Outcome


  • Drugs, Chinese Herbal
  • Placebos
  • ningdong