Medicinal properties of fractionated acetone/water neem [Azadirachta indica] leaf extract from Nigeria: a review

Niger J Physiol Sci. 2009 Dec;24(2):157-9. doi: 10.4314/njps.v24i2.52926.


The global scenario is now supporting the development of modern drugs from less toxic plant products with proven medicinal properties. Each part of neem plant [Azadirachta indica A. Juss] reportedly have various medicinal properties and has been in use in many continents for centuries. Recently, a fractionated neem-leaf extract known as IRAB with reported activities against Malaria, HIV/AIDS and cancer has been developed into a drug and currently marketed in Nigeria as IRACAP. This paper reviews the medicinal properties, clinical studies and safety concerns of this fractionated acetone-water neem leaves extract as a footstep to further studies both on the extract and/or its chemical constituents.

Publication types

  • Review

MeSH terms

  • Acetone / chemistry
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use*
  • Antimalarials / adverse effects
  • Antimalarials / therapeutic use*
  • Antineoplastic Agents, Phytogenic / adverse effects
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Azadirachta*
  • Chemical Fractionation
  • Humans
  • Medicine, African Traditional*
  • Nigeria
  • Plant Extracts / adverse effects
  • Plant Extracts / therapeutic use*
  • Plant Leaves
  • Plants, Medicinal
  • Solvents / chemistry
  • Water / chemistry


  • Anti-HIV Agents
  • Antimalarials
  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Solvents
  • Water
  • Acetone