High-flow nasal cannula and extubation success in the premature infant: a comparison of two modalities

J Perinatol. 2010 Dec;30(12):805-8. doi: 10.1038/jp.2010.38. Epub 2010 Mar 18.


Objective: To compare the effectiveness of Fisher and Paykel (FP) and Vapotherm (VT) high-flow nasal cannula (HFNC) in preventing reintubation either within 72 h or <7 days after extubation of premature infants. The primary outcome was the rate of extubation failure defined as reintubation within 72 h. Secondary outcomes included reintubation after ≤7 days.

Study design: This was a prospective, randomized pilot study comparing the extubation success of 40 infants born between 26 and 29 weeks of gestation.

Result: The rate of extubation failure at 72 h was 18% for FP and 9% for VT. The failure rate ≤7 days after extubation was 30% for FP and 27% for VT. None of these differences were statistically significant.

Conclusion: There was no difference between FP and VT in the extubation success of infants born between 26 and 29 weeks.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Dioxide / blood
  • Continuous Positive Airway Pressure / instrumentation*
  • Equipment Design
  • Female
  • High-Frequency Ventilation / instrumentation*
  • Humans
  • Infant, Extremely Low Birth Weight*
  • Infant, Newborn
  • Infant, Very Low Birth Weight*
  • Intubation, Intratracheal / instrumentation*
  • Male
  • Oxygen / blood
  • Pilot Projects
  • Prospective Studies
  • Respiratory Distress Syndrome, Newborn / therapy*
  • Respiratory Insufficiency / therapy*
  • Ventilator Weaning*


  • Carbon Dioxide
  • Oxygen