Drug discovery: inhibitors that activate

Nature. 2010 Mar 18;464(7287):358-9. doi: 10.1038/464358a.
No abstract available

Publication types

  • Comment
  • News

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Enzyme Activation / drug effects
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Humans
  • MAP Kinase Signaling System / drug effects*
  • Melanoma / drug therapy
  • Melanoma / pathology
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Models, Biological
  • Neoplasms / chemically induced*
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Protein Kinase Inhibitors / adverse effects
  • Protein Kinase Inhibitors / pharmacology*
  • Protein Kinase Inhibitors / therapeutic use
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors
  • Proto-Oncogene Proteins B-raf / genetics*
  • Proto-Oncogene Proteins B-raf / metabolism*
  • raf Kinases / antagonists & inhibitors*
  • raf Kinases / chemistry
  • raf Kinases / genetics
  • raf Kinases / metabolism*
  • ras Proteins / genetics
  • ras Proteins / metabolism

Substances

  • Protein Kinase Inhibitors
  • Adenosine Triphosphate
  • Proto-Oncogene Proteins B-raf
  • raf Kinases
  • Extracellular Signal-Regulated MAP Kinases
  • Mitogen-Activated Protein Kinase Kinases
  • ras Proteins