Induction of a diffuse mesothelioma in chickens by intraperitoneal inoculation of v-src DNA

Virology. 1991 Jun;182(2):423-9. doi: 10.1016/0042-6822(91)90583-w.


The presence of peritoneum-based, cytokeratin-positive tumor cells, as detected under conditions of intravenous inoculation of chickens with a v-src-positive DNA fragment, raised the possibility that such DNA may be inductive for diffuse mesothelioma. To investigate this possibility, chickens were inoculated intraperitoneally with v-src DNA, and the resultant peritoneum-based tumor tissue was subjected to histopathological analysis. On the basis of (i) morphology, (ii) immunohistochemistry/histochemistry, and (iii) ultrastructure, we concluded that this tissue represents a diffuse mesothelioma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics*
  • Chickens
  • DNA, Viral / genetics
  • Genes, src*
  • Injections, Intraperitoneal
  • Mesothelioma / genetics*
  • Mesothelioma / pathology
  • Oncogene Protein pp60(v-src) / genetics*


  • DNA, Viral
  • Oncogene Protein pp60(v-src)