Abstract
The amount of sparfloxacin uptake was higher than that of norfloxacin uptake in Staphylococcus aureus. Moreover, energy-dependent reduction in quinolone uptake, probably due to active efflux of the quinolone, was observed. The reduction in quinolone uptake appeared to be associated with quinolone resistance in S. aureus.
MeSH terms
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Anti-Infective Agents / metabolism*
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Anti-Infective Agents / pharmacology
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Carbonyl Cyanide m-Chlorophenyl Hydrazone / pharmacology
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Drug Resistance, Microbial
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Fluoroquinolones*
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Microbial Sensitivity Tests
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Norfloxacin / metabolism*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / metabolism*
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Carbonyl Cyanide m-Chlorophenyl Hydrazone
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Norfloxacin
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sparfloxacin