Homologues of insulinase, a new superfamily of metalloendopeptidases

N D Rawlings; A J Barrett

doi:10.1042/bj2750389

Homologues of insulinase, a new superfamily of metalloendopeptidases

Biochem J. 1991 Apr 15;275 ( Pt 2)(Pt 2):389-91. doi: 10.1042/bj2750389.

Authors

N D Rawlings¹, A J Barrett

Affiliation

¹ Department of Biochemistry, Strangeways Research Laboratory, Cambridge, U.K.

Abstract

On the basis of a statistical analysis of an alignment of the amino acid sequences, a new superfamily of metalloendopeptidases is proposed, consisting of human insulinase, Escherichia coli protease III and mitochondrial processing endopeptidases from Saccharomyces and Neurospora. These enzymes do not contain the 'HEXXH' consensus sequence found in all previously recognized zinc metalloendopeptidases.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Escherichia coli / enzymology
Escherichia coli / genetics
Humans
Insulysin / genetics*
Metalloendopeptidases / genetics*
Mitochondria / enzymology
Molecular Sequence Data
Neurospora / enzymology
Neurospora / genetics
Saccharomyces cerevisiae / enzymology
Saccharomyces cerevisiae / genetics
Sequence Homology, Nucleic Acid
Software

Substances

Metalloendopeptidases
Insulysin