An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

Neuron. 1991 May;6(5):691-704. doi: 10.1016/0896-6273(91)90167-x.


We have used PCR to identify 13 novel protein-tyrosine kinase genes (tyro-1 to -13), six of which (tyro-1 to -6) are preferentially expressed in the developing vertebrate nervous system. The tyro-2 and tyro-9 genes encode kinase domains that exhibit strong amino acid sequence similarity to the equivalent regions of the receptors for EGF and FGF, respectively, and may encode novel receptors for these or related polypeptide ligands. The tyro-1 to -6 genes are all expressed during central nervous system neurogenesis and exhibit distinct and highly regionalized patterns of expression in the adult brain. Together with recent studies in invertebrates, these data are consistent with the hypothesis that protein-tyrosine kinases play a central role in neural development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Brain / metabolism
  • Cells, Cultured
  • ErbB Receptors / genetics
  • Gene Expression Regulation
  • Gene Expression*
  • Molecular Sequence Data
  • Nervous System / embryology
  • Nervous System / metabolism*
  • Polymerase Chain Reaction
  • Protein-Tyrosine Kinases / biosynthesis
  • Protein-Tyrosine Kinases / genetics*
  • RNA Probes
  • RNA, Messenger
  • Rats
  • Sequence Homology, Nucleic Acid


  • RNA Probes
  • RNA, Messenger
  • ErbB Receptors
  • Protein-Tyrosine Kinases