Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity

J Antibiot (Tokyo). 1991 Mar;44(3):282-7. doi: 10.7164/antibiotics.44.282.

Abstract

A novel antibiotic, designated lydicamycin, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin was active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria.

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Cryptococcus neoformans / drug effects*
  • Fatty Alcohols / pharmacology
  • Fermentation
  • Gram-Positive Bacteria / drug effects*
  • Methicillin Resistance
  • Microscopy, Electron
  • Molecular Structure
  • Pyrrolidinones / pharmacology
  • Soil Microbiology
  • Staphylococcus aureus / drug effects
  • Streptomyces / classification*
  • Streptomyces / metabolism
  • Streptomyces / ultrastructure

Substances

  • Anti-Bacterial Agents
  • Fatty Alcohols
  • Pyrrolidinones
  • lydicamycin