Effects of ciguatoxin on nerve excitability in rats (Part I)

J Neurol Sci. 1991 Jan;101(1):87-92. doi: 10.1016/0022-510x(91)90021-x.


Ciguatera poisoning is the most common fish food poisoning encountered in man. Electrophysiological studies were performed on the ventral nerve of the tail on adult rats following intraperitoneal injection of toxic fish extract. Significant slowing of both mixed and motor nerve conduction velocities and F wave responses were recorded. Motor and mixed nerve amplitudes were significantly reduced. Both absolute and supernormal periods were significantly prolonged together with an exaggeration of the supernormal response. These findings indirectly suggest that ciguatoxin acts on mammalian nerve by prolonging sodium channel activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Ciguatoxins / isolation & purification
  • Ciguatoxins / toxicity*
  • Electric Stimulation
  • Male
  • Mice
  • Mice, Neurologic Mutants
  • Motor Neurons / drug effects
  • Motor Neurons / physiology*
  • Muscles / innervation
  • Neural Conduction / drug effects
  • Neurotoxins*
  • Peripheral Nerves / drug effects
  • Peripheral Nerves / physiology*
  • Rats
  • Rats, Inbred Strains
  • Reference Values
  • Skin / innervation


  • Neurotoxins
  • Ciguatoxins