Specific binding of antigenic peptides to cell-associated MHC class I molecules

Nature. 1991 May 2;351(6321):72-4. doi: 10.1038/351072a0.


T lymphocytes recognize antigen in the form of peptides that associate with specific alleles of class I or class II major histocompatibility (MHC) molecules. By contrast with the clear MHC allele-specific binding of peptides to purified class II molecules purified solubilized class I molecules either bind relatively poorly or show degenerate specificity. Using photo-affinity labelling, we demonstrate here the specific interaction of peptides with cell-associated MHC class I molecules and show that this involves metabolically active processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Affinity Labels
  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antigens, Protozoan / immunology*
  • Binding, Competitive
  • Cell Line
  • Histocompatibility Antigens Class I / immunology*
  • Kinetics
  • L Cells / immunology
  • Mice
  • Molecular Sequence Data
  • Plasmodium berghei / immunology*
  • Protein Binding
  • Protozoan Proteins*
  • T-Lymphocytes / immunology*


  • Affinity Labels
  • Antibodies, Monoclonal
  • Antigens, Protozoan
  • Histocompatibility Antigens Class I
  • Protozoan Proteins
  • circumsporozoite protein, Protozoan