Effects of phosphatidylserine in age-associated memory impairment

Neurology. 1991 May;41(5):644-9. doi: 10.1212/wnl.41.5.644.

Abstract

We treated 149 patients meeting criteria for age-associated memory impairment (AAMI) for 12 weeks with a formulation of phosphatidylserine (100 mg BC-PS tid) or placebo. Patients treated with the drug improved relative to those treated with placebo on performance tests related to learning and memory tasks of daily life. Analysis of clinical subgroups suggested that persons within the sample who performed at a relatively low level prior to treatment were most likely to respond to BC-PS. Within this subgroup, there was improvement on both computerized and standard neuropsychological performance tests, and also on clinical global ratings of improvement. The results suggest that the compound may be a promising candidate for treating memory loss in later life.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Animals
  • Female
  • Humans
  • Male
  • Memory / drug effects
  • Memory Disorders / drug therapy*
  • Memory Disorders / etiology
  • Middle Aged
  • Phosphatidylserines / therapeutic use*
  • Psychological Tests

Substances

  • Phosphatidylserines