Confidence intervals for post-test probability

Stat Med. 1991 Mar;10(3):443-56. doi: 10.1002/sim.4780100316.

Abstract

Confidence intervals are a natural way to describe the uncertainty of post-test probability in diagnostic tests. We consider confidence intervals for two different scenarios. At a site, for example, hospital emergency room or student health centre, with measured values of disease prevalence, sensitivity and specificity available, the confidence interval is similar to results in the literature, but at a site where measured values of these indices are unavailable, we develop a method, using the values of disease prevalence, sensitivity and specificity from other sites, to obtain a confidence interval for post-test probability. We use the diagnosis of strep throat to illustrate the results. We also obtain confidence intervals from simulations to compare with the results of both scenarios.

MeSH terms

  • Adult
  • Bayes Theorem
  • Clinical Laboratory Techniques / statistics & numerical data*
  • Confidence Intervals*
  • Humans
  • Models, Biological
  • Models, Statistical
  • Pharyngitis / diagnosis
  • Pharyngitis / epidemiology
  • Predictive Value of Tests
  • Prevalence
  • Probability
  • Sensitivity and Specificity
  • Streptococcal Infections / diagnosis
  • Streptococcal Infections / epidemiology