Topical corticosteroids are widely used on the human skin. The activity of corticosteroids are influenced by their molecular structure. Their action is believed to be mediated through binding to specific glucocorticosteroid receptors in the cytoplasm of cells. The beneficial clinical effects topical corticosteroids are due mainly to its anti-inflammatory property. Percutaneous absorption of topical corticosteroids is affected by variables relating to: (a) the steroid molecular itself, (b) the vehicle in which the ingredient is incorporated and, (c) the skin itself. All these factors must be taken into account in the evaluation of their activity. The more potent the topical corticosteroid, the greater the propensity to cause unwanted effects. Many adverse effects have been reported. Physicians should learn to use these drugs judiciously so as to maximise their desired effects and to minimise their undesired effects.