Behavioural effects of peripherally injected interleukin-1: role of prostaglandins

Brain Res. 1991 Mar 1;542(2):330-5. doi: 10.1016/0006-8993(91)91587-q.


To investigate the possible mediation by prostaglandins of changes in behaviour induced by peripheral injection of interleukin-1 (IL-1), two types of behavioural tests were chosen, social exploration in mice and schedule-controlled behaviour in rats. Mice treated with 1 and 2.5 micrograms recombinant human IL-1 beta showed a time- and dose-dependent decrease in exploration of a juvenile conspecific. This effect was completely blocked by pretreatment with 10 mg/kg indomethacin or 10 mg/kg piroxicam, but not with 50 mg/kg aspirin. The disruption of operant responding induced by 5 micrograms IL-1 in rats was also suppressed by pretreatment with 5 mg/kg indomethacin or 10 mg/kg piroxicam. These results indicate that prostaglandins mediate the behavioural effects of peripherally injected IL-1.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Behavior, Animal / drug effects*
  • Behavior, Animal / physiology
  • Exploratory Behavior / drug effects
  • Indomethacin / pharmacology
  • Injections
  • Interleukin-1 / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C3H
  • Motor Activity / drug effects
  • Piroxicam / pharmacology
  • Prostaglandins / physiology*
  • Social Behavior


  • Anti-Inflammatory Agents, Non-Steroidal
  • Interleukin-1
  • Prostaglandins
  • Piroxicam
  • Indomethacin