Pubertal growth and growth hormone secretion

Endocrinol Metab Clin North Am. 1991 Mar;20(1):165-82.


A dramatic increase in linear growth velocity, often referred to as the pubertal growth spurt, is a central feature of pubertal development. Despite the existence of numerous investigative attempts, a precise understanding of the hormonal events subserving this process has proved elusive. Nevertheless, evidence has gradually accumulated that indicates that sex steroid-induced modulation of growth hormone secretion is a central and critical feature of the pubertal growth spurt. As a result, disorders of either growth hormone or sex steroid hormone production may result in clinical growth disorders during puberty.

Publication types

  • Review

MeSH terms

  • Body Height
  • Female
  • Gonadal Steroid Hormones / physiology
  • Growth
  • Growth Hormone / biosynthesis
  • Growth Hormone / metabolism*
  • Humans
  • Insulin-Like Growth Factor I / physiology
  • Male
  • Puberty / physiology*


  • Gonadal Steroid Hormones
  • Insulin-Like Growth Factor I
  • Growth Hormone