The nuclear envelope

Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a000539. doi: 10.1101/cshperspect.a000539.


The nuclear envelope (NE) is a highly regulated membrane barrier that separates the nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different proteins that have been implicated in chromatin organization and gene regulation. Although the nuclear membrane enables complex levels of gene expression, it also poses a challenge when it comes to cell division. To allow access of the mitotic spindle to chromatin, the nucleus of metazoans must completely disassemble during mitosis, generating the need to re-establish the nuclear compartment at the end of each cell division. Here, I summarize our current understanding of the dynamic remodeling of the NE during the cell cycle.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Nucleus / metabolism
  • Cell Proliferation
  • Chromatin / chemistry
  • Cytoplasm / metabolism
  • Humans
  • Mitosis
  • Models, Biological
  • Nuclear Envelope / metabolism*
  • Saccharomyces cerevisiae / metabolism
  • Spindle Apparatus / metabolism*


  • Chromatin