Cytokines and other mediators in alopecia areata

Mediators Inflamm. 2010;2010:928030. doi: 10.1155/2010/928030. Epub 2010 Mar 11.

Abstract

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-gamma, interleukins, TNF-alpha, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments.

Publication types

  • Review

MeSH terms

  • Alopecia Areata / immunology*
  • Alopecia Areata / pathology
  • Cyclopropanes / immunology
  • Cytokines / immunology*
  • Hair Follicle / immunology
  • Hair Follicle / pathology
  • Humans
  • Inflammation Mediators / immunology*
  • Interferon-gamma / immunology
  • Leukocytes, Mononuclear / metabolism
  • Macrophage Migration-Inhibitory Factors / immunology
  • Major Histocompatibility Complex / immunology
  • Stress, Physiological
  • Tumor Necrosis Factor-alpha / immunology
  • fas Receptor / immunology

Substances

  • Cyclopropanes
  • Cytokines
  • Inflammation Mediators
  • Macrophage Migration-Inhibitory Factors
  • Tumor Necrosis Factor-alpha
  • fas Receptor
  • Interferon-gamma
  • diphenylcyclopropenone