Effects of repetitive training at low altitude on erythropoiesis in 400 and 800 m runners

Int J Sports Med. 2010 Jun;31(6):382-8. doi: 10.1055/s-0030-1248328. Epub 2010 Mar 18.


Classical altitude training can cause an increase in total hemoglobin mass (THM) if a minimum "dose of hypoxia" is reached (altitude >or=2,000 m, >or=3 weeks). We wanted to find out if repetitive exposure to mild hypoxia during living and training at low altitude (<2,000 m) for several weeks, often performed by elite athletes, might also have significant effects on erythropoiesis. THM, erythropoietin (EPO), soluble transferrin receptor (sTfR) and ferritin were determined in 8 elite runners before and after each of 2 training camps at low altitude interspersed by 3 weeks of sea-level training and at the same time points in a control group (CG) of 5 well-trained runners. EPO, sTfR and ferritin were also repeatedly measured during the altitude training camps. Repeated measures ANOVA revealed significant increases in EPO- and sTfR-levels during both training camps and a significant decrease in ferritin indicating enhanced erythropoietic stimulation during living and training at low altitude. Furthermore, significant augmentation of THM by 5.1% occurred in the course of the 2 altitude training camps. In conclusion, repetitive living and training at low altitude leads to a hypoxia-induced increase in erythropoietic stimulation in elite 400 m and 800 m runners and, apparently, might also cause a consecutive augmentation of THM.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Altitude*
  • Athletic Performance / physiology
  • Erythropoiesis / physiology*
  • Female
  • Germany
  • Humans
  • Hypoxia / physiopathology
  • Male
  • Running / physiology*
  • Young Adult