Genetic Disorders of Glycan Degradation

In: Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 41.


This chapter explores the degradation and turnover of glycans in lysosomes, especially with respect to human genetic disorders. Delineation of the dismantling of a few representative glycans illustrates features unique to different pathways. The degradation of oligomannosyl N-glycans removed from misfolded, newly synthesized glycoproteins is covered in Chapter 36.

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