Hereditary Spastic Paraplegia Overview

In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.
[updated ].


The purpose of this overview is to increase the awareness of clinicians regarding hereditary spastic paraplegia.

The following are the goals of this overview.

Goal 1: Describe the clinical characteristics of hereditary spastic paraplegia and recommended treatment.

Goal 2: Review the causes of hereditary spastic paraplegia.

Goal 3: Consider the differential diagnosis of hereditary spastic paraplegia.

Goal 4: Provide an evaluation strategy to identify the genetic cause of hereditary spastic paraplegia in a proband.

Goal 5: Inform genetic counseling of family members of a proband with hereditary spastic paraplegia.

Publication types

  • Review