Stability of buffered lidocaine and epinephrine used for local anesthesia

J Dermatol Surg Oncol. 1991 May;17(5):411-4. doi: 10.1111/j.1524-4725.1991.tb03975.x.


Buffered lidocaine has been recently recommended for local anesthesia, as there is less pain on injection of the buffered solution. Reduced pain on injection of lidocaine and epinephrine buffered to a neutral pH was confirmed in 20 subjects (P less than .01). Concentrations of buffered lidocaine and epinephrine were performed in order to evaluate their stability. Buffered lidocaine dropped to 66.1% of initial concentrations after 4 weeks when stored at 25 degrees C. Buffered epinephrine fell to 1.34% of its initial concentration under similar conditions. Buffered lidocaine and epinephrine maintained 94.54% and 82.04%, respectively, of their initial concentrations after 4 weeks when refrigerated at 0-4 degrees C. Both lidocaine and epinephrine maintained greater than 90% concentration 2 weeks after buffering when stored at 0-4 degrees C. This permits batch buffering of lidocaine with epinephrine and storage for periods up to 2 weeks when properly refrigerated.

MeSH terms

  • Anesthesia, Local*
  • Buffers
  • Drug Combinations
  • Drug Stability
  • Drug Storage
  • Epinephrine / adverse effects
  • Epinephrine / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Lidocaine / adverse effects
  • Lidocaine / chemistry*
  • Pain / etiology
  • Pain / physiopathology
  • Pain / prevention & control
  • Pain Measurement
  • Temperature


  • Buffers
  • Drug Combinations
  • Lidocaine
  • Epinephrine