A presumed case of phantom limb pain treated successfully with duloxetine and pregabalin

Gen Hosp Psychiatry. Mar-Apr 2010;32(2):228.e5-7. doi: 10.1016/j.genhosppsych.2009.05.012. Epub 2009 Jul 3.

Abstract

Phantom limb pain (PLP) may occur in nearly 80% of amputation patients. Current research has highlighted several changes that occur in the nociception pathway post amputation. With this knowledge, novel therapies were found that could decrease PLP. Two such drugs are duloxetine and pregabalin, each effecting unique steps in the nociception pathway. We also review the neurobiology and efficacy of this treatment strategy.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / therapeutic use*
  • Drug Therapy, Combination
  • Duloxetine Hydrochloride
  • Female
  • Humans
  • Middle Aged
  • Nociceptors / physiology
  • Pain / diagnosis
  • Pain / drug therapy*
  • Pain / etiology*
  • Phantom Limb / complications*
  • Pregabalin
  • Serotonin Uptake Inhibitors / therapeutic use*
  • Thiophenes / therapeutic use*
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Anticonvulsants
  • Serotonin Uptake Inhibitors
  • Thiophenes
  • Pregabalin
  • gamma-Aminobutyric Acid
  • Duloxetine Hydrochloride