Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity?

Transfus Med Rev. 2010 Apr;24(2):125-9. doi: 10.1016/j.tmrv.2009.11.003.


Because most extremely preterm infants with birth weight less than 1000 g need red blood cell transfusions, many attempts have been made to collect, process, and store placental blood (ie, umbilical cord blood) for autologous transfusions. Although it is feasible to do this, multiple problems in doing so including insufficient volumes collected, clotting, hemolysis, bacterial contamination, failure to significantly supplant need for allogeneic transfusions, and high costs have led many to question whether, on balance, autologous/placental red blood cell transfusion offers clinically significant benefits.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anemia, Neonatal / therapy*
  • Blood Transfusion, Autologous / statistics & numerical data*
  • Erythrocyte Transfusion / statistics & numerical data*
  • Female
  • Fetal Blood / transplantation*
  • Health Services Needs and Demand
  • Humans
  • Infant, Newborn
  • Placental Circulation / physiology
  • Pregnancy