A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome

Leuk Res. 2010 Dec;34(12):1566-72. doi: 10.1016/j.leukres.2010.02.021. Epub 2010 Mar 29.


Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Angiopoietin-1 / biosynthesis
  • Antigens, CD34*
  • Apoptosis*
  • Cell Cycle*
  • Cytochrome b Group / biosynthesis
  • DNA Damage*
  • DNA Repair*
  • Female
  • Gene Expression Regulation*
  • HSP70 Heat-Shock Proteins / biosynthesis
  • Humans
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / metabolism*
  • Oncogene Protein p55(v-myc) / biosynthesis
  • Oxidoreductases / biosynthesis


  • ANGPT1 protein, human
  • Angiopoietin-1
  • Antigens, CD34
  • Cytochrome b Group
  • HSP70 Heat-Shock Proteins
  • HSPA1B protein, human
  • Oncogene Protein p55(v-myc)
  • Oxidoreductases
  • CYBRD1 protein, human