Privileged scaffolds for library design and drug discovery

Curr Opin Chem Biol. 2010 Jun;14(3):347-61. doi: 10.1016/j.cbpa.2010.02.018. Epub 2010 Mar 18.


This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Drug Delivery Systems / methods
  • Drug Discovery / methods*
  • Humans
  • Models, Chemical*
  • Pharmaceutical Preparations / chemistry
  • Protein Binding
  • Receptors, Cytoplasmic and Nuclear / chemistry
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Small Molecule Libraries / chemical synthesis
  • Small Molecule Libraries / chemistry*


  • Pharmaceutical Preparations
  • Receptors, Cytoplasmic and Nuclear
  • Small Molecule Libraries