Tumor delivery of macromolecular drugs based on the EPR effect

Adv Drug Deliv Rev. 2011 Mar 18;63(3):131-5. doi: 10.1016/j.addr.2010.03.011. Epub 2010 Mar 18.


Enhanced permeability and retention (EPR) effect is the physiology-based principal mechanism of tumor accumulation of large molecules and small particles. This specific issue of Advanced Drug Delivery Reviews is summing up multiple data on the EPR effect-based drug design and clinical outcome. In this commentary, the role of the EPR effect in the intratumoral delivery of protein and peptide drugs, macromolecular drugs and drug-loaded long-circulating pharmaceutical nanocarriers is briefly discussed together with some additional opportunities for drug delivery arising from the initial EPR effect-mediated accumulation of drug-containing macromolecular systems in tumors.

Publication types

  • Review

MeSH terms

  • Animals
  • Capillary Permeability*
  • Drug Delivery Systems*
  • Extravasation of Diagnostic and Therapeutic Materials / metabolism
  • Extravasation of Diagnostic and Therapeutic Materials / physiopathology*
  • Gene Transfer Techniques*
  • Humans
  • Macromolecular Substances / metabolism*
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / physiopathology


  • Macromolecular Substances