Vitamin D supplementation suppresses age-induced bone turnover in older women who are vitamin D deficient

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):293-6. doi: 10.1016/j.jsbmb.2010.03.054. Epub 2010 Mar 19.


There is a lack of evidence that improving vitamin D status, without changing calcium intake, has a positive effect on bone turnover as indicated by bone marker changes. The objective was to measure the effect of vitamin D supplementation, in vitamin D deficient women (25(OH)D concentration<50 nmol/L), on osteocalcin (OC) and C-telopeptide (CTX). The study design was a randomised controlled intervention administering 4000 IU vitamin D3 or placebo daily for 6 months to South Asian women, aged>20 years. Subjects were stratified by age and menopausal status. Median (25th, 75th percentile) serum 25(OH)D increased significantly from 21 (11, 40) to 75 (55, 84) nmol/L with supplementation. In women>49 years or postmenopausal (n=26), who were not supplemented (n=13), CTX and OC levels increased (P=0.001, P=0.004 respectively), indicating an increased rate of bone turnover. With supplementation CTX decreased (P=0.012) and there was no significant change in OC. In women who were under 49 years and premenopausal (n=55; 29 supplemented), there was no significant response to supplementation in either CTX or OC. We conclude that correcting vitamin D deficiency in older women suppresses the age-induced increase in bone turnover and reduces bone resorption which would normally be exacerbated in conditions of low serum 25(OH)D.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aging*
  • Bone Density
  • Bone Resorption
  • Bone and Bones / drug effects
  • Bone and Bones / metabolism
  • Collagen Type I / metabolism
  • Dietary Supplements*
  • Female
  • Humans
  • Middle Aged
  • Osteocalcin / metabolism
  • Osteoclasts / drug effects
  • Peptides / metabolism
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / metabolism*


  • Collagen Type I
  • Peptides
  • collagen type I trimeric cross-linked peptide
  • Osteocalcin
  • Vitamin D