Visual outcomes in five different approaches for treatment of central retinal vein occlusion

Ophthalmic Surg Lasers Imaging. Mar-Apr 2010;41(2):157-65. doi: 10.3928/15428877-20100303-02.

Abstract

Background and objective: Four treatment methods for central retinal vein occlusion were compared with its natural course.

Patients and methods: In this partially prospective, comparative, interventional case series on 63 eyes with central retinal vein occlusion, five approaches were compared: intravitreal triamcinolone injection; radial optic neurotomy; combined radial optic neurotomy and intraocular triamcinolone injection; combined internal limiting membrane peeling, radial optic neurotomy, and intraocular triamcinolone; and observation.

Results: Final visual acuity in the intravitreal triamcinolone group was better compared with the observation (P = .025), radial optic neurotomy (P = .037), combined radial optic neurotomy/intraocular triamcinolone injection (P = .401), and combined internal limiting membrane peeling, radial optic neurotomy, and intraocular triamcinolone injection (P = .023) groups. However, after adjustment for baseline visual acuity, the only treatment method with significant visual acuity improvement in relation to the observation group was the combined radial optic neurotomy/intraocular triamcinolone injection (P = .025, .023, and .054 at 1, 3, and 6 months, respectively).

Conclusion: Among the five different approaches analyzed in this study, combined radial optic neurotomy and intraocular triamcinolone injection may provide a better visual outcome in the management of central retinal vein occlusion.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Decompression, Surgical / methods
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fundus Oculi
  • Glucocorticoids / administration & dosage*
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Optic Nerve / surgery*
  • Prospective Studies
  • Retinal Vein Occlusion / diagnosis
  • Retinal Vein Occlusion / physiopathology
  • Retinal Vein Occlusion / surgery*
  • Treatment Outcome
  • Triamcinolone Acetonide / administration & dosage*
  • Visual Acuity*
  • Vitrectomy / methods*
  • Vitreous Body
  • Young Adult

Substances

  • Glucocorticoids
  • Triamcinolone Acetonide